Viagra is a brand name given to the drug Sildenafil Citrate. It is sold by a company called Pfizer. It is the primary drug which is prescribed by many doctors across the world to treat impotence and erectile dysfunction. The drug works to produce an enzyme called cGMP which causes the high blood flow to penis causing prolonged erection.
Viagra is a brand name of the drug Sildenafil Citrate and is the best known drug prescribed at all times to treat erectile dysfunction. It was introduced in 1998 by British scientists and since then it is the first prescribed drug to treat impotence. It is the class of drug known as PDE-5 (Phosphodiesterase type 5) inhibitors. The drug works to enhance and boost the erectile response when a man is sexually aroused. Before the introduction of this blue colored pill, Phentolamine injection was used to treat these erectile issues. The greatest advantage of this drug as a pill is that it causes erection only when the man is sexually stimulated whereas in Phentolamine there is uncontrolled and immediate erection.
The Working Procedure of the Drug
The stuff works in a very simple way. To know about the working procedure of the drug it is also important to know the physiological mechanism of erection. When a person is sexually aroused the brain sends a signal to the nerve fiber. These nerve cells called as NANC produce nitric oxide and release it to the surrounding cells which help to stimulate the enzyme guanylate cyclase. Guanylate cyclase in turn produces a messenger like chemical called guanosine monophosphate (cGMP). This cGMP makes the smooth muscles in the artery to loosen up and dilate. When they dilate the blood flow to penis also increases. The pill works by maintaining the level of cGMP and cGMP is produced only when the brain releases nitric oxide. If there is no arousal then another enzyme by the name phosphodiesterase works to deactivate the cGMP levels.
When a person take the pill, the Sildenafil Citrate in the pill is released into the blood stream and works to eliminate the PDE enzyme which inhibits the cGMP levels. As a result the body builds more cGMP and has a larger dilation effect on the arteries allowing heavy blood flow; so the greater the blood flow, the greater the erection. Also the pill works with the brain and helps to release nitric oxide in the body, which again boosts the cGMP chemical levels. Even though the Sildenafil Citrate flows throughout the body it reacts only with the PDE5 enzyme. The drug stays in the blood for at least 4 hours and later it is excreted or washed away with the help of liver and kidneys.
The side effects associated with this drug are often exaggerated. For instance some people say that this drug lowers the blood pressure. However in actual, the effect is more only when the pill is taken with other nitrate drugs. Nitrates are often prescribed to treat angina so when the pill is taken with nitrates it may lower the blood pressure.
The active ingredient in Viagra is Sildenafil Citrate. The chemical formula for this Sildenafil Citrate is C22H30N6O4S. For best results it is advised to take the pill on empty stomach. When taken with food it does not serve its purpose. It should be taken one hour prior to the sexual activity so that erection is possible in 30- 60 minutes. Taking it only once a day is advisable, if taken more than once it may lead to adverse effects.